Human Anatomy and Physiology Textbook

Progressive massive fibrosis( PMF)

Caplan syndrome( with RA)

Silicosis, eg sandblasting

Asbestosis: Mining, milling, and fabrication; installation and removal of insulation

Pleural plaques

Caplan syndrome

Mesothelioma

Carcinoma of the lung, larynx, stomach, colon

Byssinosis : cotton in Textile manufacturing

Particles that are 1 to 5 μm are the most dangerous, because they get lodged at the bifurcation of the distal airways.

particles greater than 5 to 10 μm are unlikely to reach distal airways

particles smaller than 0.5 μm tend to act like gases and move into and out of alveoli

Silica, asbestos, and beryllium are more reactive than coal dust, resulting in fibrotic reactions at lower concentrations

Usually these harmful particles are entrapped in the mucus blanket and rapidly removed from the lung by ciliary movement

The pulmonary alveolar macrophage mediate an inflammatory response and initiate fibroblast proliferation and collagen deposition

Tobacco smoking worsens the effects of all inhaled mineral dusts

asymptomatic anthracosis

simple coal workers pneumoconiosis (CWP

complicated CWP or progressive massive fibrosis (PMF)

Caplan syndrome if associated with Rheumatoid Arthritis

PMF has a tendency to progress even in the absence of further exposure

upper lobes are predominantly involved

coal macules and coal nodule

centrilobular emphysema.