Human Anatomy and Physiology Textbook

It is the oldest member of bactericidal antibiotics . Sir Alexander  Fleming discovered penicillin in 1928.

In 1940 Chain , Folery and their  associates first produce significant quantities  of penicillin from cultures of Penicillium  notatum . 

Penicillins are lipid insoluble. 

Cannot cross the blood brain barrier.

Can cross the placental barrier.

Source of Penicillin :

1. Natural : Penicillum notatum (previously)

Penicillium chrysogennum (now a day )

2. Synthetic.

3. Semisynthetic.