Monday, March 16, 2015
Rapidly Progressive Glomerulonephritis RPGN
Type I RPGN (Anti-GBM Antibody)
Idiopathic
Goodpasture syndrome
Type II RPGN (Immune Complex)
Idiopathic
Postinfectious
Systemic lupus erythematosus
Henoch-Schönlein purpura (IgA)
Type III RPGN (Pauci-Immune)
ANCA associated
Idiopathic
Wegener granulomatosis
Microscopic polyarteritis nodosa/microscopic polyangiitis
proliferation of the parietal epithelial cells of Bowmans capsule in response to injury and in part by infiltration of monocytes and macrophages forms crescents
crescents eventually obliterate Bowmans space and compress the glomeruli
Crescentic glomerulonephritis (PAS stain). Note the collapsed glomerular tufts and the crescent-shaped mass of proliferating cells and leukocytes internal to Bowman capsule.
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